Facts about mesenchymal stem cells

Bone marrow primitive mesenchymal stem cells are bone marrow stromal stem cells. They are a subpopulation of cells found in mammalian bone marrow stromal cells that have multiple differentiation potentials to form bone, cartilage, fat, nerves and myoblasts. They not only have mechanical support for hematopoietic stem cells (HSC) in the bone marrow, but also secrete a variety of growth factors (such as IL-6, IL-11, LIF, M-CSF, and SCF) to support haemopoiesis. Mesenchymal stem cells (MSCs) are a type of early undifferentiated cells that have the characteristics of self-renewal, self-replication, unlimited proliferation, and multidirectional differentiation. They can secrete cytokines to reduce inflammation, reduce tissue cell apoptosis, and promote proliferate and perform immune regulation of endogenous stem progenitor cells, so as to achieve the effect of repairing tissues and organs. After continuous subculture and cryopreservation, it still has the potential for multi-directional differentiation, which is called “universal cells” in the medical community.

Functions of mesenchymal stem cells

  1. Multi-directional differentiation: they have strong proliferation ability and multi-directional differentiation potential;
  2. Immunomodulation: they are low immunogenicity, with immunoregulatory function. They won’t cause immune rejection, and can inhibit rejection;
  3. Rich in quantity: they are rich in various tissues and easy to collect.
  4. Strong fertility: up to 1 billion cells can be cultured in vitro for multiple uses.
  5. Safe and reliable: their genes are stable, not easy to mutate, and still have the characteristics of stem cells after multiple passages.
  6. Awide range of application: they have a wide range of applications and can be used to treat almost all tissue damage, aging and degenerative diseases.

Applications of mesenchymal stem cells in humans

  1. The cells are differentiated into functional cells, replacing functional cells that are in decline or injury;
  2. Start the sequential expression of regeneration-related genes, so that endogenous decline of tissues and organs and damage repair are initiated;
  3. Exogenous cells enter the body, secrete a variety of growth nutrition factors, and improve the internal microenvironment of tissues and organs;
  4. Immunomodulation can reduce the inflammatory response of local tissues and organs;
  5. Activate and improve the quality of immune cells and eliminate and prevent hidden diseases
  6. Differentiate skeletal muscle cells, make fat distribution even, muscles firm, muscles and bones soft;
  7. Promote collagen production, a variety of growth factors secreted by cells, effectively regulate the endocrine system and hormone system.

Diseases available for mesenchymal stem cells

① Hematological diseases: mainly for leukemia;

②Nervous system diseases: such as Parkinson’s syndrome, Alzheimer’s disease, traumatic brain injury, spinal cord injury, motor neuron disease, etc .;

③ Parenchymal organ damage or disease: such as cirrhosis and its complications, lung and other tissue fibrosis;

④ Immune system diseases: mainly use the immune regulation of stem cells, such as systemic lupus erythematosus, rheumatoid arthritis, etc .;

⑤ Cardiovascular diseases: such as myocardial infarction, vascular disease, ischemic heart disease, etc .;

⑥ Metabolic diseases: such as diabetes and its complications;

⑦ Patellar joint diseases: such as osteoarthritis, femoral head necrosis, etc .;

⑧Reproductive system diseases: such as premature ovarian failure, endocrine disorders, etc.

⑨ Other fields, such as corneal stem cells for eye diseases, stem cell anti-aging, etc.

Creative Biolabs can provide phenotypic, genetic, and functional assessments of your MSC population of interest using various techniques and tools. We adapt to your requirements by providing either individual service modules or a fully comprehensive service package.