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  • On September 26, UCLA researcher reported the outcome of a study, which indicated that Asians who are struggling with alcoholism may benefit especially from naltrexone, considered one of three medications authorized by the U.S. Food and Drug Administration (FDA) for your treatment of alcoholism. Recent research has discovered that a gene variant may predict naltrexone treatment success for alcoholism. About 50% of patients of Asian descent have a particular mutation that produces them planning to benefit from naltrexone, in contrast to about 20% of Caucasians and fewer than 5% of African Americans, said lead study author Lara Ray, an assistant professor of psychology and director with the UCLA Addictions Laboratory. The findings are presently available online ( inside journal Neuropsychopharmacology and are published in an upcoming print edition of the journal.

    Using two separate drugs to shed pounds can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people who go through it you should err along the side of caution and allow FDA do its job and demand some research be done so the public is aware of the side effects and risks of the medications before we bring them. Keep in mind that drug companies will be in business to generate money and that they would say everything to keep people on the medications.

    Researchers found that participants using this drug for a year, dropped excess weight within 4 weeks and have kept the weight off through the 56 weeks with the study. Contrave is a combination from the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which might be made up of multiple active ingredient, which can make them more effective and safer.

    Combo-pilling will be the newest fad or better yet the newest in the future under scrutiny and for that reason it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills has become popular could be the fact that since right now there are not any long term prescription weight loss supplements that have been licensed by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be authorized by the FDA.

    Seizures really are a side effect with Contrave and mustn’t be taken in people who have seizure disorders. The drug also can raise blood pressure levels and heart rate, and really should not be used in individuals with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug.

    The FDA also warned that Contrave can raise blood pressure level and heart rate and must not be used in patients with uncontrolled high blood pressure level, as well as by you are not heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients using a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients towards the increased likelihood of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stop smoking.

    From a psychiatric point of view, evidence implies that the ordinary neural mechanism for goal-directed behavior may be hijacked through the addiction, and malfunctions in such a way that its ordinary functions are exaggerated and fixated on its object. An object creates a stimulus as well as the person engages in a “goal-directed behavioral response” that generates a “natural high”(Bostwick & Bucci, 2008).